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Depression, post-traumatic stress disorder, and social anxiety
The review published in Clinical Psychology Review assessed all published scientific literature that investigated the use of marijuana to treat symptoms of mental illness.Its authors found some evidence supporting the use of marijuana to relieve depression and post-traumatic stress disorder symptoms.That being said, they caution that marijuana is not an appropriate treatment for some other mental health conditions, such as bipolar disorder and psychosis.The review indicates that there is some evidence to suggest that marijuana might alleviate symptoms of social anxiety, but again, this is contradicted by the National Academies of Sciences, Engineering, and Medicine review, which instead found that regular users of marijuana may actually be at increased risk of social anxiety.
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Evidence suggests that oral cannabinoids are effective against nausea and vomiting caused by chemotherapy, and some small studies have found that smoked marijuana may also help to alleviate these symptoms.Some studies on cancer cells suggest that cannabinoids may either slow down the growth of or kill some types of cancer. However, early studies that tested this hypothesis in humans revealed that although cannabinoids are a safe treatment, they are not effective at controlling or curing cancer.
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Dravet syndrome seizures are prolonged, repetitive, and potentially lethal. In fact, 1 in 5 children with Dravet syndrome do not reach the age of 20.
In the study, 120 children and teenagers with Dravet syndrome, all of whom were aged between 2 and 18, were randomly assigned to receive an oral cannabidiol solution or a placebo for 14 weeks, along with their usual medication.The researchers found that the children who received the cannabidiol solution went from having around 12 seizures per month to an average of six seizures per month. Three children receiving cannabidiol did not experience any seizures at all.Children who received the placebo also saw a reduction in seizures, but this was slight — their average number of seizures went down from 15 each month before the study to 14 seizures per month during the study.The researchers say that this 39 percent reduction in seizure occurrence provides strong evidence that the compound can help people living with Dravet syndrome, and that their paper has the first rigorous scientific data to demonstrate this.However, the study also found a high rate of side effects linked to cannabidiol. More than 9 in 10 of the children treated with cannabidiol experienced side effects — most commonly vomiting, fatigue, and fever.
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At the other end of the spectrum is the plethora of studies that have found negative associations between marijuana use and health. They are listed below.
Mental health problems
Daily marijuana use is believed to exacerbate existing symptoms of bipolar disorder among people who have this mental health problem. However, the National Academies of Sciences, Engineering, and Medicine report suggests that among people with no history of the condition, there is only limited evidence of a link between marijuana use and developing bipolar disorder.
Moderate evidence suggests that regular marijuana users are more likely to experience suicidal thoughts, and there is a small increased risk of depression among marijuana users.
Marijuana use is likely to increase risk of psychosis, including schizophrenia. But a curious finding among people with schizophrenia and other psychoses is that a history of marijuana use is linked with improved performance on tests assessing learning and memory.